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We engineered a series of NTD mutants based on our structural analysis, aiming to disrupt the binding between the CBMs and the Chc boxes (see Methods)

One-carbon cofactor intake and risk of neural tube defects among women who meet folic acid recommendations: a multicenter case-control study

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This suppression was specific to lipids, as GLP-1RA and dual agonist treatment in rats on a choice paradigm assessing individual palatable macronutrients robustly inhibited intake of Crisco (lipid) without decreasing intake of a sucrose (carbohydrate) solution